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Quick summary

Type of medicine

Topical Cream



Active Ingredient

Clobetasone Butyrate, Oxytetracycline, Nystatin

Effective within

Varies by individual and condition; typically within a few days of use

Works by

Reducing inflammation, addressing bacterial and fungal infections

Side effects

Skin irritation, redness, thinning of the skin (atrophy), stretch marks (striae), increased hair growth (hypertrichosis), perioral dermatitis, and more (consult healthcare provider)

Medication details


Trimovate Cream is a prescription medication available in the United Kingdom. It is classified as a topical corticosteroid and is used for the treatment of various inflammatory skin conditions. This cream combines three active ingredients to address different aspects of skin issues: Clobetasone Butyrate, Oxytetracycline, and Nystatin.


How to Use Trimovate Cream
Preparation: Start by ensuring that the affected area is clean and dry.
Application: Apply a thin layer of Trimovate Cream to the affected skin.
Massage: Gently massage the cream into the skin until it is absorbed.
Hand Hygiene: After application, wash your hands thoroughly, unless your hands are the treated area.
Dosage Instructions
The specific dosage and frequency of Trimovate Cream will be determined by your healthcare provider. Generally, it is applied once or twice daily. Always follow your healthcare provider's instructions.


Active Ingredients in Trimovate Cream
Clobetasone Butyrate (0.05% w/w): A topical corticosteroid that reduces inflammation, itching, and redness in the skin.
Oxytetracycline (3% w/w): An antibiotic that helps prevent or treat bacterial skin infections.
Nystatin (100,000 units w/w): An antifungal medication used to address fungal infections.
Inactive Ingredients
Trimovate Cream also contains inactive ingredients such as:
White soft paraffin
Liquid paraffin
Macrogol stearate
Cetostearyl alcohol
Potassium sorbate
Purified water
These inactive ingredients help stabilize the product, improve its texture, and prolong its shelf life.

Side Effects

Some common side effects of Trimovate Cream include:
Skin irritation, redness, or a burning sensation at the application site.
Thinning of the skin (atrophy).
Development of stretch marks (striae).
Increased hair growth (hypertrichosis).
Perioral dermatitis (a rash around the mouth).
These side effects are typically mild and temporary. If they persist or worsen, consult your healthcare provider.
Less Common Side Effects
Less common side effects may include:
Allergic reactions (rash, itching, swelling).
Skin infections.
Acne-like eruptions (steroid acne).
Changes in skin pigmentation.
If you experience any unusual or severe side effects, seek medical attention promptly.


Before using Trimovate Cream, consider the following precautions:
Hypersensitivity: If you are allergic to any of the ingredients in Trimovate Cream, do not use it.
Infections: Avoid using Trimovate Cream on untreated skin infections unless directed by your healthcare provider.
Thin Skin Areas: Use caution when applying this cream to thin skin areas, such as the face or genitals.
Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Trimovate Cream with your healthcare provider.

Medically reviewed and published

  • This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Oct 5, 2023, 2:45 pm

How it works

Start a consultation for your condition, select a treatment option, and our in-house clinicians will review and prescribe if suitable. Expect your order within 1-3 working days.

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Please read our FAQs page to find out more.

Is Trimovate Cream available over the counter (OTC)?

No, Trimovate Cream is not available over the counter. It is a prescription medication, which means you need a prescription from a healthcare provider to obtain it. This is because it contains active ingredients that require professional evaluation and guidance for safe and effective use.

Can Trimovate Cream be used for acne treatment?

Trimovate Cream is not typically prescribed for acne treatment. It contains a combination of active ingredients primarily designed to address inflammatory skin conditions such as eczema, contact dermatitis, and psoriasis. If you have concerns about acne, it's best to consult with a dermatologist or healthcare provider who can recommend appropriate acne treatments.

How long can I use Trimovate Cream continuously?

The duration of Trimovate Cream usage should be determined by your healthcare provider. It is not recommended for long-term continuous use without medical supervision. Prolonged use of topical corticosteroids like clobetasone butyrate can lead to skin thinning and other side effects. Your healthcare provider will provide guidance on the appropriate treatment duration for your specific condition.

Can I use cosmetics or other skincare products alongside Trimovate Cream?

It's important to consult with your healthcare provider before using other skincare products, including cosmetics, while using Trimovate Cream. Some products may interact with Trimovate or exacerbate skin irritation. Your healthcare provider can advise you on which products are safe to use in conjunction with Trimovate Cream.

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