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Quick summary

Type of medicine

Ocular Lubricant (Eye Drops)

Works by

Providing artificial tears and lubrication to relieve dry eye symptoms

Active Ingredient

Polyethylene Glycol 400 (PEG 400) and Propylene Glycol

Effective within

Rapid relief within minutes of application


No (Brand Name Product)

Side effects

Mild eye irritation, temporary blurred vision, watery eyes, redness or discomfort at the application site. Allergic reactions are rare but possible.

Medication details


Systane Ultra Eye Drops stand as a trusted solution for individuals grappling with the discomfort of dry eyes. Dry eye syndrome, or dry eye disease, is a prevalent ocular condition characterized by insufficient moisture or lubrication on the surface of the eye. It can manifest as symptoms like itchiness, burning sensations, redness, gritty feelings, and blurred vision. These symptoms often result from an inadequate quantity or poor quality of natural tears.

Systane Ultra Eye Drops are engineered to alleviate these distressing symptoms effectively. They are designed to mimic the composition of the eye's natural tears, providing long-lasting relief and comfort. The advanced formulation of Systane Ultra incorporates a precise combination of active ingredients that work synergistically to address the underlying causes of dry eye.

Dry eye can occur for various reasons, including environmental factors, aging, certain medical conditions, and medication side effects. Regardless of the cause, the goal of Systane Ultra is to soothe the irritation and restore a more comfortable and clearer vision.

The eye drops are suitable for individuals experiencing occasional or chronic dry eye symptoms. Whether your dry eyes are due to prolonged screen time, contact lens wear, exposure to windy or dry environments, or medical conditions like meibomian gland dysfunction, Systane Ultra offers relief that can make a significant difference in your daily comfort and visual clarity.


Wash Hands: Before using Systane Ultra Eye Drops, ensure your hands are clean and dry.

Remove the Cap: Twist off the cap of the eye drop bottle.
Tilt Head Back: Gently tilt your head backward, looking upward.

Pull Lower Eyelid: With one hand, gently pull down your lower eyelid to create a small pocket.

Apply Drops: Hold the eye drop bottle upside down over your eye and squeeze it to release one or two drops into the pocket created by your lower eyelid. Avoid touching the dropper tip to any surface, including your eye.

Close Eye: Close your eye gently and blink a few times to help spread the solution evenly.

Repeat if Necessary: If you need to administer drops to both eyes, repeat the process for the other eye.

Replace Cap: Securely replace the cap on the eye drop bottle.

Avoid Contamination: Be careful not to contaminate the tip of the bottle, as this can lead to infection. Keep the bottle tightly closed when not in use.

Use as Directed: Follow the instructions provided on the product packaging or those given by your healthcare professional.


Systane Ultra Eye Drops contain the following active and inactive ingredients:

Active Ingredients:
Polyethylene Glycol 400 (PEG 400)
Propylene Glycol
Inactive Ingredients:
Hydroxypropyl Guar
Boric Acid
Potassium Chloride
Sodium Chloride
POLYQUAD® (Polyquaternium-1) 0.001% preservative
It's important to note that the specific formulation of eye drops may vary slightly between different products within the Systane range. Always check the product label for the most accurate ingredient information.

Side Effects

Systane Ultra Eye Drops are generally well-tolerated. However, like all medications, they may cause side effects in some individuals. Common side effects may include:

Mild eye irritation
Blurred vision (temporary)
Watery eyes
Redness or discomfort at the application site
Allergic reactions (rare but possible)

If you experience any severe or persistent side effects, discontinue use and seek medical attention. Consult with a healthcare professional if you have concerns about the side effects of Systane Ultra Eye Drops.


Consult a Healthcare Professional: If you experience persistent eye discomfort, changes in vision, or if your condition worsens after using Systane Ultra Eye Drops, consult a healthcare professional.

Allergies: If you are allergic to any of the ingredients in Systane Ultra Eye Drops, do not use this product. Always check the product label for allergen information.

Contact Lenses: Remove contact lenses before using the eye drops and wait at least 15 minutes before reinserting them.

Storage: Store Systane Ultra Eye Drops at room temperature and away from direct sunlight. Keep the bottle tightly closed when not in use.

Pregnancy and Nursing: If you are pregnant, nursing, or planning to become pregnant, consult with a healthcare professional before using this product.

Keep Out of Reach of Children: Store the eye drops out of the reach of children. If accidentally ingested, seek medical help immediately.

Medically reviewed and published

  • This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Oct 5, 2023, 2:30 pm

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Please read our FAQs page to find out more.

How quickly does Systane Ultra provide relief from dry eyes?

Systane Ultra Eye Drops are known for their rapid action in alleviating dry eye discomfort. Users often report experiencing relief within just a few minutes of application. The formulation is designed to provide quick and effective moisture to the eyes, helping to soothe irritation and discomfort for several hours after use.

Can I safely use Systane Ultra Eye Drops while wearing contact lenses?

Yes, Systane Ultra Eye Drops are compatible with contact lens wear. To ensure optimal comfort, it's recommended to remove your contact lenses before applying the drops. After applying the drops, wait at least 15 minutes before reinserting your contact lenses. This allows the solution to work effectively without any interference from the lenses.

Are there any age restrictions for using Systane Ultra?

Systane Ultra Eye Drops are generally safe for individuals of all age groups. Whether you're a young adult or an elderly person experiencing dry eye symptoms, Systane Ultra can provide relief. However, if you have specific concerns, especially when administering the drops to a child or older adult, it's advisable to consult a healthcare professional for personalized guidance.

Can I use Systane Ultra Eye Drops in combination with other eye medications?

If you are considering using Systane Ultra Eye Drops alongside other eye medications, it's essential to consult with a healthcare professional or pharmacist. They can provide expert advice on the compatibility of different eye treatments and help you prevent potential interactions. Your eye health is unique, and personalized guidance is crucial to ensure the best results.

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