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Quick summary

Type of medicine

Ocular Lubricant (Eye Drops)

Works by

Providing immediate and lasting moisture to relieve dry eye symptoms

Active Ingredient

Hydroxypropyl Guar and Polyethylene Glycol 400 (PEG 400)

Effective within

Rapid relief within minutes of application


No (Brand Name Product)

Side effects

Temporary blurred vision, mild eye irritation, watery eyes, redness or discomfort at the application site. Allergic reactions are rare but possible.

Medication details


Systane Hydration Eye Drops are a trusted and clinically-proven solution for addressing dry eye symptoms. Dry eye syndrome, also known as dry eye disease, is a common condition that occurs when the eyes do not produce enough tears or when the quality of tears is compromised. This can lead to symptoms such as irritation, burning, itching, redness, and a sensation of grittiness.

Systane Hydration Eye Drops are specifically formulated to provide relief for dry eyes. They work by providing immediate and long-lasting moisture to the ocular surface. These eye drops contain a unique blend of active ingredients that closely mimic the composition of natural tears, ensuring comfort and hydration for those experiencing dryness and discomfort.

Whether you have occasional dry eye symptoms or suffer from chronic dry eye, Systane Hydration Eye Drops offer an effective way to manage this condition and enjoy clearer, more comfortable vision.


Clean Hands: Start by washing your hands thoroughly with soap and water to ensure they are clean and free from contaminants.

Remove the Cap: Carefully twist off the cap of the Systane Hydration Eye Drops bottle.

Tilt Head Back: Gently tilt your head backward while looking upward.

Lower Eyelid: Using one hand, gently pull down your lower eyelid to create a small pocket.

Apply Drops: Hold the eye drop bottle upside down over your eye and squeeze it to release one or two drops into the pocket created by your lower eyelid. Be cautious not to touch your eye with the dropper tip or any other surface.

Close Eye: Close your eye gently and blink a few times to help evenly distribute the solution.

Repeat if Necessary: If you need to treat both eyes, repeat the process for the other eye.

Replace Cap: Securely replace the cap on the eye drop bottle to prevent contamination.

Storage: Store Systane Hydration Eye Drops at room temperature, away from direct sunlight, and ensure the bottle is tightly closed when not in use.

Follow Instructions: Always follow the usage instructions on the product packaging or those provided by your healthcare professional.


Systane Hydration Eye Drops contain the following active and inactive ingredients:

Active Ingredients:
Hydroxypropyl Guar
Polyethylene Glycol 400 (PEG 400)
Inactive Ingredients:
Boric Acid
Calcium Chloride
Magnesium Chloride
Potassium Chloride
Purified Water
Sodium Borate
Sodium Chloride
These ingredients are carefully balanced to provide optimal hydration and comfort to dry eyes.

Side Effects

Systane Hydration Eye Drops are generally well-tolerated. However, as with any medication, some individuals may experience side effects. Common side effects may include:
Temporary blurred vision
Mild eye irritation
Watery eyes
Redness or discomfort at the application site
Allergic reactions (rare but possible)
If you experience severe or persistent side effects, discontinue use and seek medical attention. Consult with a healthcare professional if you have concerns about the side effects of Systane Hydration Eye Drops.


Consult a Healthcare Professional: If you experience ongoing eye discomfort, changes in vision, or worsening of symptoms after using Systane Hydration Eye Drops, consult a healthcare professional for a thorough evaluation.

Allergies: Avoid using Systane Hydration Eye Drops if you are allergic to any of the ingredients listed on the product packaging.

Contact Lenses: Remove contact lenses before applying the eye drops and wait at least 15 minutes before reinserting them. Systane Hydration Eye Drops are suitable for use with both soft and hard contact lenses.

Pregnancy and Nursing: If you are pregnant, nursing, or planning to become pregnant, consult with a healthcare professional before using this product.

Keep Out of Reach of Children: Store the eye drops out of the reach of children. In case of accidental ingestion, seek medical assistance promptly.

Use with Caution: While there are no specific interactions reported with alcohol, it's advisable to use Systane Hydration Eye Drops with caution if you consume alcohol, especially if you experience severe dry eye symptoms, as alcohol can exacerbate dryness.

Medically reviewed and published

  • This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Oct 5, 2023, 2:30 pm

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Please read our FAQs page to find out more.

Can I use Systane Hydration Eye Drops with other eye medications?

Yes, Systane Hydration Eye Drops are generally safe to use in conjunction with other eye medications. However, it's advisable to consult a healthcare professional or pharmacist for personalized guidance if you plan to use multiple eye treatments simultaneously.

Is it safe to use Systane Hydration Eye Drops before or after eye surgery?

If you are scheduled for eye surgery or have recently undergone one, it's crucial to follow your surgeon's recommendations regarding the use of eye drops. They will provide specific instructions tailored to your surgical procedure and recovery.

Can I use Systane Hydration Eye Drops if I have allergies to common eye drop ingredients?

Systane Hydration Eye Drops have a unique formulation, but individuals with known allergies to any of the listed ingredients should avoid using the product. Always check the product label for allergen information and consult with a healthcare professional for alternative options if you have allergies.

Is Systane Hydration Eye Drops safe for long-term use?

Systane Hydration Eye Drops are designed for both short-term and long-term use to manage dry eye symptoms. They are preservative-free, making them suitable for continuous use as needed. However, it's advisable to consult with a healthcare professional for ongoing guidance if you require prolonged use.

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