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Quick summary

Type of medicine

Sleep Aid



Active Ingredient

Diphenhydramine Hydrochloride 25mg

Effective within

Approximately 20 minutes

Works by

Promoting Relaxation and Drowsiness

Side effects

Drowsiness, Dry Mouth

Medication details


Nytol Original 25mg is a night-time sleep aid that works quickly to reduce time taken to fall asleep. Its active ingredient (promethazine hydrochloride) helps reduce wakefulness, allowing for a more restful sleep - a perfect choice for those having difficulty sleeping without the next day grogginess.


Using Nytol Original 25mg is a simple and effective way to enhance your sleep routine:
Take one tablet about 20 minutes before your desired bedtime.
Swallow the tablet whole with a glass of water, allowing it to be easily absorbed.
Create a comfortable sleep environment by dimming the lights, minimizing noise, and ensuring a cozy bed.
Give yourself time to unwind and relax before sleep. Engage in calming activities, such as reading or gentle stretching.
Avoid stimulating substances like caffeine and nicotine in the hours leading up to bedtime.
Limit screen time and exposure to electronic devices, as the blue light emitted can interfere with your body's natural sleep signals.
By incorporating Nytol Original 25mg into your nightly routine, you're making a conscious choice to prioritize your sleep quality and overall health.


Nytol Original 25mg contains a key active ingredient that contributes to its sleep-promoting effects:

Diphenhydramine Hydrochloride 25mg: This antihistamine is renowned for its sedative properties, helping you experience a sense of calmness and drowsiness that aids in falling asleep.

Nytol Original 25mg's formulation is designed to work with your body's natural processes, gently encouraging relaxation and preparing you for a peaceful night's rest. Each tablet contains the optimal amount of diphenhydramine to facilitate sleep without causing grogginess the next day.

Side Effects

While Nytol Original 25mg is well-tolerated by many individuals seeking improved sleep, it's important to note potential side effects that can occur:

Drowsiness: Due to its sedative nature, you may experience drowsiness upon waking. It's recommended to ensure you have enough time for rest before engaging in activities that require alertness.

Dry Mouth: A temporary dry mouth can occur, a common side effect of certain antihistamines.
It's essential to remember that side effects are generally mild and transient. If you encounter any discomfort or unusual reactions, consult a healthcare professional for guidance.


Prior to incorporating Nytol Original 25mg into your routine, consider the following precautions:
Avoid Alcohol: Refrain from consuming alcohol while taking Nytol Original 25mg, as it can intensify the sedative effects and increase the likelihood of drowsiness.
Consult a Professional: If you are pregnant, breastfeeding, or have underlying health conditions, consult a healthcare provider before using Nytol Original 25mg.
Short-Term Use: Nytol Original 25mg is intended for short-term use to address occasional sleeplessness. Prolonged use is not recommended, and it's important to explore the underlying causes of sleep difficulties with a medical professional.
Not for Children: This product is not suitable for individuals under 16 years of age.
Nytol Original 25mg is designed to offer gentle support in achieving the sleep your body deserves. Embrace the restorative power of restful sleep and awaken each morning feeling rejuvenated and ready to face the day's challenges.

Medically reviewed and published

  • This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Aug 24, 2023, 3:30 pm

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Please read our FAQs page to find out more.

Can I take half a tablet of Nytol Original 25mg for a milder effect?

Nytol Original 25mg tablets are formulated for a specific dosage of diphenhydramine hydrochloride to provide effective sleep support. Altering the dosage by splitting the tablet may impact its efficacy and consistency. For personalized advice, consult a healthcare professional before adjusting the recommended dose.

How long should I wait after taking Nytol Original 25mg before going to bed?

After taking Nytol Original 25mg, allow approximately 20 minutes for the sedative effects to take effect. During this time, engage in calming activities and create a comfortable sleep environment to maximize the benefits of the product.

Is Nytol Original 25mg habit-forming, or can I use it occasionally?

Nytol Original 25mg is designed for occasional use to address short-term sleep difficulties. It is formulated to avoid dependency and grogginess upon waking. To explore long-term sleep solutions, consider consulting a healthcare provider to identify and manage underlying sleep issues.

Can I take Nytol Original 25mg along with other medications?

Before combining Nytol Original 25mg with other medications, including over-the-counter or prescription drugs, consult a healthcare professional. Interactions may occur, and your healthcare provider can guide you on the best approach to ensure safety and effectiveness.

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