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Quick summary

Type of medicine

Sleep Aid



Active Ingredient

Diphenhydramine Hydrochloride 50mg

Effective within

Approximately 20 minutes

Works by

Promoting Relaxation and Drowsiness

Side effects

Drowsiness, Dry Mouth

Medication details

Nytol One-A-Night 50mg is a medication used to help people who have difficulty falling asleep. It contains the active ingredient diphenhydramine hydrochloride, which works by blocking the effects of histamine in the brain to promote drowsiness. Nytol One-A-Night 50mg is taken as a single tablet before bedtime and is available over-the-counter without a prescription. It should only be used as directed and may cause drowsiness the following day.

Incorporating Nytol One a Night 50mg into your sleep routine is a straightforward process that can enhance your sleep quality:

Take one tablet approximately 20 minutes before your intended bedtime.
Swallow the tablet whole with a glass of water, ensuring smooth ingestion and optimal absorption.
As you prepare for sleep, create an environment conducive to relaxation. Dim the lights and minimize exposure to screens, allowing your body to naturally wind down.
Engage in calming activities, such as reading or gentle stretches, to ease your mind and prepare it for sleep.

To maximize the benefits of Nytol One a Night 50mg, avoid stimulants such as caffeine and nicotine in the hours leading up to bedtime.
By incorporating Nytol One a Night 50mg into your nightly routine, you're investing in your sleep quality and overall well-being. Restful sleep not only revitalizes your body but also enhances your mental clarity and emotional resilience.


Nytol One a Night 50mg features a key active ingredient that plays a pivotal role in its sleep-promoting effects:

Diphenhydramine Hydrochloride 50mg: This antihistamine is known for its sedative properties, inducing relaxation and drowsiness that facilitate falling asleep naturally.

By targeting receptors in the brain responsible for wakefulness, diphenhydramine helps initiate and maintain a tranquil sleep state.

Nytol One a Night 50mg's formulation ensures that you experience the full benefits of this active ingredient to enjoy uninterrupted, restorative sleep.

Side Effects

While Nytol One a Night 50mg is generally well-tolerated, it's important to be aware of potential side effects that may arise:

Drowsiness: As a result of its sedative nature, you may experience drowsiness upon waking. Plan for sufficient rest time before resuming your daily activities.

Dry Mouth: Temporary dry mouth is a common side effect of certain antihistamines, including diphenhydramine.

It's crucial to note that side effects are typically mild and transient. If you encounter any discomfort or unusual reactions, consult a healthcare professional for personalized guidance.


Before incorporating Nytol One a Night 50mg into your routine, take the following precautions:

Alcohol Interaction: Refrain from consuming alcohol while using Nytol One a Night 50mg. Alcohol can amplify the sedative effects, potentially leading to increased drowsiness.

Consult a Professional: If you are pregnant, breastfeeding, or have underlying medical conditions, consult a healthcare provider before using Nytol One a Night 50mg.

Short-Term Use: Nytol One a Night 50mg is intended for short-term use to address occasional sleeplessness. Extended use is not recommended, and it's essential to explore underlying sleep issues with medical guidance.

Not for Children: This product is not suitable for individuals under 16 years of age.

Nytol One a Night 50mg offers a reliable solution for those seeking to improve their sleep quality. By choosing this product, you're taking proactive steps toward embracing rejuvenating sleep and enjoying the vitality it brings to your waking hours.

Medically reviewed and published

  • This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Aug 24, 2023, 3:30 pm

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Please read our FAQs page to find out more.

Can I split the Nytol One a Night 50mg tablet into smaller doses for gradual effect?

Nytol One a Night 50mg tablets are specifically formulated as a single dose to provide optimal sleep support. Altering the tablet's dosage by splitting it may affect its efficacy and consistency. For personalized advice on using the product, consult a healthcare professional before making any changes.

Is Nytol One a Night 50mg suitable for shift workers struggling with irregular sleep patterns?

Yes, Nytol One a Night 50mg can offer support to individuals with irregular sleep schedules, including shift workers. Consult a healthcare provider to determine the best timing for taking the tablet based on your work hours and sleep routine.

Can I use Nytol One a Night 50mg with other sleep aids or supplements?

It's recommended to consult a healthcare professional before combining Nytol One a Night 50mg with other sleep aids or supplements. While Nytol One a Night 50mg is designed to promote restful sleep, interactions between different products may occur.

What should I do if I accidentally miss taking a Nytol One a Night 50mg tablet before bedtime?

If you accidentally miss a dose of Nytol One a Night 50mg, it's advisable to skip that dose. Do not double the dose to make up for the missed tablet. Consistency in dosage and timing is important for optimal sleep support.

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